The leaflet inside at least needs to be changed to have the correct information on it. Im wondering if after it is out of his system or have I now poisoned my baby where he might have a seizure disorder for the rest of his life. Took her to her Vet where I was told she had another tremor. He has no appetite. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. for flea and ticks? However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. Seriously I have had the worse luck. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . My 11 year old mini Aussie has been taking Simparica 1.5 years. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. Her blood work came back fine. So sorry to hear, and good for you in recognizing the problem! Im going to keep a close watch on him over the next few days. She hasnt eaten in 3 days and is unable to go up 2 simple steps. Everything else in his environment, world has remained the same. Its now about May 16th 2021. He was diagnosed with "Sundowners" . Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. I was furious with the drug and the prescriber too. Bella is a very anxious dog and is my husbands shadow. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. Not long after ingesting the chewable she began to have tremors, but not full blown seizures. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . I thought maybe he got into something. Hey carol im so sorry to hear about your dog? Does your do still have a cough? Today is Friday. Then on day 5 my poor dog just couldnt move. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. Especially, Camelia who lost her furbaby because of a seizure that was apparently brought on by this medication. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. around 12 years She grabs and won't let go. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. This behavior is so inconsistent and confusing. Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. I am so angry. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. I brought him to the vet and they keep trying to say excessive water drinking isnt a side effect but its the only thing that is different that Ive given my pup. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. Can you tell me if your dog is back to normal now?!?! Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. I feel like the simperica trio has somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them. I had to put him laundry room for the night (no Carpet). Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . I dont know. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. Mine is due for another dose next week and I don't know what to do. My 15 yr old doodle wasnt given bravecto because of reviews. I hope the best for you and dog, I know its a tough time. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. $37.98 with Subscribe & Save discount. I am so mad at myself for letting the vet talk me into this. I also am seeking information as to if there is a class action suit against this company because there should be. Our new vet has recommended Simperica, but I wont be giving it to my Collie. Please do not use this drug. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. He already has canine dementia on and off. The Maltese mix is lethargic and wont jump on bed or couch. He has never acted like he was in pain. From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. Pyrantel Pamoate was first approved in 1977 for the treatment and . At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. Now we are waiting for the verdict: whether its an infection in his bladder or stones. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . I dont like that my dog looks at me like he doesnt know who I am. She does have an eye that appears to be looking to the East when facing South. Thank you for this information. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! When I bathe him the scabs fall off and I think, oh good, this problem is going away. Her last dose of Simparica Trio was given to her on October 1, 2021. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Very common in: Dogs of any age, breed, or gender can experience vomiting. My nearly 14 year old Havanese Kokomo has taken a sharp decline in the last 8 month and I was blaming it on old age when I think I may have been poisoning him. On 08/06 she threw up. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. The same thing possibly is happening to my 9 month old Boxador. But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. Then they come back! I wish every one the best. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. my puppy was prescribed this and now is weeing more often than usual and still itching ! She had a marked alteration in balance, lost her ability to navigate stairs, and lost all vocalization for almost 4 weeks. RELATED: Signs Your Dog Might Be Having a Seizure. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. Today shes acting better, finally, but her back legs are still collapsing and she is weak. She was terrified and we were too. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. I have my 14 week old pup simparica (vet recommended) 2 days ago. Thanks! What scared me and caused me to start doing some more research is while drinking he stops and acts as if he has a lot of peanut butter in his mouth. 24 hours later she had another one. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. old . The vet recognized immediately that she was in severe neurogical distress. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. Thankfully there have been no other side effects. Anything I can do for him? In total we spend around $780 trying to control/stop the tremors & seizures. He is acting very skittish/scared like behavior, wants to just lay down. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. But unfortunately it's only a dog is the big Pharma tune. He said it would take care of ticks and Trifexis doesn't. My 12 yr-old Chihuahua mix is losing his hair right above his nose. Im worried sick. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). Vet trip and meds $400! Can blocking GABA receptors also cause inflammation of spine? Did you do this yourself or let the vet? My dog steadily went downhill after I gave her the first dose of simparica. It's only available with a prescription from your veterinarian, so you cannot get it over-the-counter. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. That was when I lived in Fort Lauderdale. He had ONE dose that evening and completely lost his appetite within a couple days. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. Next day, he was suddenly 1000% worse, would not touch food, could not move. My Labradoodle had extreme diarrhea last night. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. This can help with feelings of anxiety, stress, and fear." He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). Has odd agitated swallowing when not eating anything. It is the flea and tick component that is the problem. Simparica can cause ataxia, which is the official name for loss of body control. Its Sunday night and still vomiting. this link is to an external site that may or may not meet accessibility guidelines. Very small sample - many deformities, stillborn. He licks his lips all the time? My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. It is better but not gone. 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