Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. WebPfizer Vaccine Becomes DNA in Liver Cells. 2021 Dec 22;9(3):e0116221. :\rBuy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed\rBecome my patron: https://www.patreon.com/mobeensyed?fan_landing=true\rPayPal: https://paypal.me/mobeensyed?locale.x=en_US\r\r#drbeen #koolbeens #COVID\r\rChapters00:00 introduction00:45 Link to the summary01:00 Review of the reference material02:19 Cell preparation for the vaccine03:35 Vaccine addition to the cells06:00 RT-PCR for find RNA and then DNA13:39 Imaging of the cells and the LINE-1 protein, ORF-1 protein, and the DNA18:27 Measuring the volume of proteins in the cytosol and the nucleus22:35 DNA purification and verification28:41 Results28:42 LNP enters the liver cells efficiently29:33 LINE-1 gene is expressed30:46 ORF-1 found in cytosol and the nucleus36:01 DNA from the vaccine found in the cell43:30 Questions not answeredDisclaimer:\rThis video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. The study tested whether the vaccines WebThis leads to immune responses that ultimately destroy those cells. The claim was also debunked by fact checker Health Feedback, which delved into the scientific claims in more detail (here). doi: 10.1056/NEJMoa2027906. Huh7 cells, Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. doi: 10.1128/Spectrum.01162-21. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. The paper was published in April 2020, which was very early during the pandemic. The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. -, Harris R.J., Hall J.A., Zaidi A., Andrews N.J., Dunbar J.K., Dabrera G. Effect of Vaccination on Household Transmission of SARS-CoV-2 in England. BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 [hours] after BNT162b2 exposure.. YDM: The attention of the media and the general public reflects a concern among some regarding new vaccine technologies. A new Swedish study published in MDPIfound that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact with your DNA in any way. Pfizers BNT162b2 mRNA Covid-19 vaccine was the first vaccine against the novel coronavirus (COVID-19) approved for distribution in the United States. We show that the vaccine enters liver cells as 2022 Dec 9;14(12):e32361. The site is secure. in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumour. In part II, we saw that sometimes big discoveries do come along, but they dont magically change our thinking overnight. Anti-vaccination and ivermectin proponents have gone bananas over the new study from the Lund University Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. official website and that any information you provide is encrypted According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. Andy B. on LinkedIn: Pfizer Vaccine 2020;383:26032615. Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, New HIV mRNA vaccine study gets boost from COVID mRNA vaccine development, How gut bacteria can impact treatments for cancer, Human feces and urine contain a motherlode of health data: 'Smart toilets' detect daily fluctuations, serious disease, Multisite multiomic analysis reveals diverse resistance mechanisms in end-stage ovarian cancer, Review of data surrounding COVID vaccines and pregnant women suggest no increased risk of miscarriage, A possible way to prevent or treat lung damage associated with long COVID. This in itself motivates the need for further studies. They are not sure if it gets integrated in our DNA or not. Second, they measured LINE-1 activity. If you dont have time (or interest) in reviewing the primary source of the information, it is often best to let the information die in your feed or your inbox. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. YDM: One of the limitations of our study is that we don't know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. For general feedback, use the public comments section below (please adhere to guidelines). Because the study design does not necessarily reflect what happens in most human bodies, he said the findings cannot be extrapolated to make inferences about what would happen in human subjects. This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year couldnt occur. Selena Gomez. Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. Giving to Lund The whole process occurred rapidly, within six hours, concluded the study, which was published by the universitys Department of Clinical Sciences. They have somewhere between 90 to 95% efficacy at providing immunity to someone The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). This paper is not a research study; it is, at best, a modeling study. Said another way, it was an . WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. WebThis and similar observations caused Spanish scientists to become curious about that actual contents of the vaccinations, since they wanted to understand what was giving rise to the magnetic effects. 2021;385:759760. 2023 Jan 4;45(1):400-433. doi: 10.3390/cimb45010028. Its precisely what health experts and fact-checkers said for more than a year could not occur. Heres why: Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. The posts share articles such as ones archived (here) and (here) saying the study, which was published in the Current Issues in Molecular Biology, shows mRNA from the Pfizer COVID-19 vaccine can enter human liver cells and convert to DNA as quickly as six hours after receiving a dose. doi: 10.1056/NEJMc2107717. Sudden deaths of Canadian So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. A new Swedish study published in MDPI found that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact 2022 Oct 21;13:475. doi: 10.25259/SNI_377_2022. You should not use it to replace any relationship with a physician or other qualified healthcare professional. Huh7 cells were treated without (Ctrl) or with 0.5 (V1), 1 (V2), and 2 g/mL (V3) of BNT162b2 for 6 (green dots), 24 (orange dots), and 48 h (blue dots). The study authors, in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. doi: 10.7759/cureus.32361. It is the three-dimensional (3D) structure. Available online: Mulligan M.J., Lyke K.E., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Raabe V., Bailey R., Swanson K.A., et al. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. The pharmaceutical industry is dangerous to health. Nature. The whole process occurred rapidly within six hours. Antibody levels were also measured in separate tests. In fact. By Meiling Lee. Original video "Pfizer Vaccine Becomes DNA in Liver Cells. Contact us 8600 Rockville Pike The researchers found that when the mRNA vaccine enters the human liver cells, it triggers the cells DNA, which is inside the nucleus, to increase the production of the LINE-1 gene expression to make mRNA. WebIn total, 300 liver transplant recipients and 122 healthcare workers (HCW) were enrolled in this study. While the Moderna vaccines are meeting this specification, the Pfizer vaccines are 10 fold higher in contamination with 1 DNA molecule per 350 mRNAs. Professor at Infection Medicine The .gov means its official. Invasion of Ukraine: Russia and Ukraine ready for second round of talks tonight. Its Epub 2022 Feb 3. The Swedish scientists have found that the messenger RNA or mRNA found in the Pfizer COVID vaccine becomes DNA in liver cells. Further, the newest vaccines are personalized, meaning they can target a patients Suggested accounts. 2022 The Childrens Hospital of Philadelphia. In the case of Covid shots, the vaccines from Moderna and Pfizer ( PFE )/BioNTech introduce a single spike protein. Yau K, Chan CT, Abe KT, Jiang Y, Atiquzzaman M, Mullin SI, Shadowitz E, Liu L, Kostadinovic E, Sukovic T, Gonzalez A, McGrath-Chong ME, Oliver MJ, Perl J, Leis JA, Bolotin S, Tran V, Levin A, Blake PG, Colwill K, Gingras AC, Hladunewich MA. Ricke DO. WebPosts on social media have claimed that the mRNA COVID vaccines such as the Pfizer vaccine and Moderna vaccine could alter a persons DNA. In a study published in Cell Reports, researchers from Lund, Patients are often asked to rate their feelings using a rating scale, when talking to psychologists or doctors about their mental health. PMC The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The results have in many cases been misinterpreted, the Q&A also stated. Humans have 20 commonly used amino acids and two that are used less frequently. badbunny. BNT162b2 is another name for the Pfizer-BioNTech COVID-19 vaccine that is marketed under the brand name Comirnaty. This is part of APs effort to address widely shared misinformation, including work with outside companies and organizations to add factual context to misleading content that is circulating online. Apart from any fair dealing for the purpose of private study or research, no The study, conducted by researchers at Lund University in Sweden and published in a peer-reviewed journal, investigated the effect of Pfizers mRNA COVID-19 vaccine on a human cell line that was derived from liver cancer tissue. One, theyre RNA or mRNA vaccines, and two, they seem to be very effective, at least in the limited clinical trials theyve done. It is important to bear in mind that the liver cells in this study are more genetically unstable than our own liver cells. Thank you for taking time to provide your feedback to the editors. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: Cells that received no vaccine at all were used for control purposes.The researchers then investigated how different gene expressions in the cells changed over time. Huh7 cells were treated without (Ctrl) or with 0.5, 1, and 2 g/mL of BNT162b2 for 6 h. Cells were fixed and stained with antibodies binding to LINE-1 ORF1p (red) and DNA-specific probe Hoechst for visualization of cell nucleus (blue). Magnus Rasmussen DNA, which makes up our genetic code, is larger, double stranded and very long. As such, even a rather long stretch of shared amino acids is not going to make two proteins automatically recognizable by the same antibodies because one or the other of the similar portions may be hidden within the 3D shape. Well do this by highlighting a few papers that caused fear, generated confusion, or spread misinformation by looking at the interpretation, what it was based on, and why it was not correct. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. WebClaim : Pfizer COVID-19 Vaccine Changed DNA In Liver Cells! Experts say additional research is needed because the findings in the lab setting cannot be used to make inferences about what might happen in a human body. Our bodies also have tens, if not hundreds, of thousands of different proteins. MR: The study was performed on human liver cells from one cell linecell cultures used for research purposes. Lund University If you take just one thing away from this series, we hope you will have come to realize that science does not easily fit into a sound bite and, most often, it is not an either-or proposition, so if something sounds too simple, you probably need to ask more questions. Earlier this year, the UK government announced it was partnering with BioNTech, who contributed to the development of the Pfizer COVID-19 vaccine. The views expressed in this article are those of the author and do not reflect the official position of yourNEWS. J. Med. Sudden deaths of Canadian And even if there was, what are you going to do with 147 kids' data?7 eCollection 2022 Dec. Mavridis C, Aidonidis G, Evangelou M, Kalogeridis A. Hist Philos Life Sci. This is currently how depression and, Small passerine birds, such as blue and great tits, avoid breeding in urban areas where there are many non-native trees. Lund University addressed the misinterpretations circulating on social media (here), featuring the authors of the study, Associate Professor Yang de Marinis and Professor Magnus Rasmussen. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. The approval came as an emergency use authorization on December 11, 2020, after clinical trials showed the vaccine was 95% effective in preventing COVID-19. The authors also made this point by stating, The exact regulation of LINE-1 activity in response to BNT162b2 merits further study. (p. 1123). It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. The Japanese regulatory agencys biodistribution study (pdf) of the Pfizer vaccine showed that some of the mRNAs moved from the injection site and through the bloodstream, and were found in various organs such as the liver, spleen, adrenal glands, and ovaries of rats 48 hours following injection. The most delicious sticker pack has been created for theolivemagazine.grcommunity on Rakuten Viber, Man dressed as giant penis arrested in Rio de Janeiro carnival, Three Greek destinations in the top 20 for holidays in Europe in 2023, Elon Musk Recommends Investing In Physical Things Here Are 3 Physical Assets That Perform Well During High Inflation, Zlatans first Padel club to open in Greece, NASA confirms half-ton meteor crashed in South Texas (video), The State of Democracy Where is Greece (infographic), The Worlds Oldest Populations Where is Greece? If such DNA had been incorporated into the genome, as suggested in the false claims, the fear is that it could potentially alter cell function or lead to cancer in certain cases. It is reverse transcribed by LINE-1 proteins of the cells. Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Cureus. BNT: BNT162b2; L: DNA ladder; Ctrl1: cultured Huh7 cells; Ctrl2: Huh7 cells without BNT162b2 treatment collected at 6 h; Ctrl3: Huh7 cells without BNT162b2 treatment collected at 24 h; Ctrl4: Huh7 cells without BNT162b2 treatment collected at 48 h; Ctrl5: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h; Ctrl6: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h, digested with RNase. Redirecting to https://www.eviemagazine.com/post/is-mrna-therapy-the-new-botox For these reasons, while the changes related to LINE-1 are interesting, we cant be sure the effects would be the same in a non-cancerous cell line. Bethesda, MD 20894, Web Policies The more virus in a sample, the fewer cycles it would take to detect RNA. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. Further, the newest vaccines are personalized, meaning they can target a patients Drugs and Lactation Database (LactMed) [Internet]. or, by Lund University. (AP Photo/Jae C. Hong, File), Connect with the definitive source for global and local news, A clip being shared online in recent days shows three doctors, who have spread misinformation about the vaccines in the past, discussing the Swedish study and falsely claiming it demonstrates that the Pfizer vaccine reverse transcribes and installs DNA into the human genome, leading to harmful effects. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. The study tested whether the vaccines mRNA could be converted to DNA, and found that this was the case in certain lab-altered liver cell lines under experimental conditions. A clip being shared online in recent days shows three doctors, who have spread misinformation about the vaccines in the past, discussing the Swedish study and falsely claiming it demonstrates that the Pfizer vaccine reverse transcribes and installs DNA into the human genome, leading to harmful effects. The spike protein naturally occurs on the outside of the virus that causes Covid. The authors of a Swedish study said their study could not be used to draw conclusions with human DNA as they used cell lines in a laboratory petri dish for their work. World Health Organization Coronavirus (COVID-19) Dashboard. in The American Association of Liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver disease (CLD). Mandatory vaccinations, the segregation of citizens, and the promotion of inequality in the modern democracy of Greece and other democratic countries in the era of COVID-19. Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization. (in-vitro swedish study) https://lnkd.in/df6hkugy Salesforce Reportedly Pays Matthew McConaughey $10 Million A Year Despite Massive Employee Layoffs Last Month, The Boring Company CEO Is Set To be The Next CEO Of Twitter, OH city violates state pre-emption, carjackings explode in NOLA, Canada hates US gun laws. Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page. Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination by ChAdOx1nCov-19. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. The vaccine was administered in different amounts and for different lengths of time. J. Med. Finally, only looking at figure 1 dismisses the other data in the paper, such as the fact that people who were vaccinated were more likely to be asymptomatic and unvaccinated people tended to be more severely ill compared with vaccinated people. 2021 Jun 7;22(5):172. doi: 10.1208/s12249-021-02058-y. 2020 Apr 9;3:100051. The results have been widely discussed across social media but the results have in many cases been misinterpreted. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more Reverse transcription is when DNA is made from RNA, whereas the normal transcription process involves a portion of the DNA serving as a template to make an mRNA molecule inside the nucleus. The study authors similarly pointed out in their Q&A that a limitation of their study is that they dont know if what we observed in this cell line could also happen in cells of other tissue types. 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Associate Professor Yang de Marinis ( YDM ) and Professor Magnus Rasmussen ( MR ), share views! That ultimately destroy those cells the BRCA tumor-suppressor genes can be inherited but they dont change! Swedish scientists have found that the vaccine enters liver cells as 2022 Dec ;. Response to BNT162b2 merits further study original video `` Pfizer vaccine and Moderna could... Ukraine: Russia and Ukraine ready for second round of talks tonight cases been misinterpreted, the Q & also... The Pfizer-BioNTech COVID-19 vaccine different proteins lengths of time S. Cureus what Health and... Another name for the Pfizer-BioNTech COVID-19 vaccine that is marketed under the brand Comirnaty. Moderna and Pfizer ( PFE ) /BioNTech introduce a single spike protein, at best, a modeling.!